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Line the base and sides of an 8-inch square baking pan with parchment paper, leaving an overhang of paper on two facing sides. (This will help you remove the caramels from the pan.) Set aside.
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In a large microwaveable bowl, combine both sugars, the corn syrup, condensed milk, butter, vanilla extract and salt.
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Microwave on high power for 6 minutes. Stirring every 2 minutes.
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Check the temperature with a candy thermometer: it should register 250℉ (120℃). If the mixture is too cool, heat for 30-second intervals until it reaches 250℉.
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Carefully pour the caramel into the prepared pan and sprinkle with sea salt flakes. Let cool at room temperature for at least 2 hours
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Using the parchment paper overhang, lift the caramel from the pan to a cutting board. With a large, sharp knife, cut into 25 pieces. (The caramels can be stored in an airtight container, individually wrapped in wax paper or cellophane for up to 1 month)